Biological activities of unique isoflavones prepared from Apios americana Medik

Haruna Kaneta, Mina Koda, Shun Saito, Masaya Imoto, Manabu Kawada, Yoko Yamazaki, Isao Momose, Kazuoshi Shindo

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1.4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.

本文言語English
ページ(範囲)774-778
ページ数5
ジャーナルBioscience, Biotechnology and Biochemistry
80
4
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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