Biological and therapeutic significance of MUC1 with sialoglycans in clear cell adenocarcinoma of the ovary

Yutaka Tamada, Hideyuki Takeuchi, Nao Suzuki, Nobuyuki Susumu, Daisuke Aoki, Tatsuro Irimura

研究成果: Article査読

10 被引用数 (Scopus)

抄録

A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas. A reverse correlation between the binding levels of this mAb and patient survival was demonstrated. To examine the role of MUC1 in ovarian clear cell carcinomas, two cDNA encoding MUC1 were transfected into ES-2 ovarian clear cell carcinoma cells. By comparing these cells, the role of MUC1 in tumorigenicity, chemosensitivity and survival under anoikis conditions were assessed. The results indicate that MUC1 expressed on ovarian clear cell carcinoma cells is causally involved in the malignant behavior.

本文言語English
ページ(範囲)1586-1591
ページ数6
ジャーナルCancer science
98
10
DOI
出版ステータスPublished - 2007 10

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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