Biological Effect of Carbon Beams on Cultured Human Cells

Wei Jei Ka, Hisao Ito, Naoyuki Shigematsu, Shoji Yamashita, Atushi Kubo, Tatsuaki Kanai

研究成果: Article査読

1 被引用数 (Scopus)

抄録

This study was performed to determine the biological effect of carbon beams on 13 human tumor cells, in comparison with 200 KVp X-rays. Carbon beams were generated by the Riken Ring Cyclotron. The RBE (relative biological effectiveness) values were distributed from 1.46 to 2.20 for LET of 20 keV/μm, and 2.29-3.54 for 80 keV/μm. The RBEs were increased in all cell lines as the LET of carbon beams was increased from 20 to 80 keV/μm. There was no significant difference in radiosensitivity between cells from adenocarcinoma and those from squamous cell carcinoma. The relationship between the radiosensitivity of cells to X-rays and RBE was analyzed, but no significant correlation was suggested. Several survival curves of 20-40 keV/μm carbon beam irradiation showed the initial shoulders and the recovery ratios between two split doses were determined. Recovery was observed for LET of 20 keV/μm but not for that of 40 keV/μm. Furthermore, recovery ratios were 1.0-1.8, smaller than those for X-rays (1.5-2.4).

本文言語English
ページ(範囲)669-673
ページ数5
ジャーナルNippon Acta Radiologica
56
9
出版ステータスPublished - 1996 8

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング
  • 腫瘍学

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