Bisebromoamide, a potent cytotoxic peptide from the marine cyanobacterium lyngbya sp. Isolation, stereostructure, and biological activity

Toshiaki Teruya, Hiroaki Sasaki, Hidesuke Fukazawa, Kiyotake Suenaga

研究成果: Article査読

102 被引用数 (Scopus)

抄録

A novel cytotoxic peptide, termed bisebromoamide (1), has been Isolated from the marine cyanobacterium Lyngbya sp. Its planar structure was determined by 1D and 2D NMR spectroscopy. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Bisebromoamide (1) exhibited potent protein kinase Inhibition: the phosphorylation of ERK In NRK cells by PDGFstimulation was selectively Inhibited by treatment with 10-0.1 μM of 1.

本文言語English
ページ(範囲)5062-5065
ページ数4
ジャーナルOrganic Letters
11
21
DOI
出版ステータスPublished - 2009 11 5

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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