Bisphenol A exerts thyroid-hormone-like effects on mouse oligodendrocyte precursor cells

Chika Seiwa, Jin Nakahara, Takatsugu Komiyama, Yoshinao Katsu, Taisen Iguchi, Hiroaki Asou

研究成果: Article査読

71 被引用数 (Scopus)

抄録

We report studies on the mechanism of action of bisphenol A (BPA) on the differentiation of oligodendrocyte precursor cells (OPCs). Our results show that: (1) BPA inhibits the differentiation of OPCs induced by exposure to thyroid hormone (T3 ). (2) The effect is mediated through various mechanisms via the thyroid hormone receptor (TRβ1) which is considered to be responsible for OPC differentiation. (3) The action of BPA on OPC differentiation does not involve the FcRγ -Fyn-myelin basic protein (MBP) cascade as an inducer of OPC differentiation nor does it suppress CREB phosphorylation, which is considered to be induced by the T3 -TR complex. (4) The presence of MBP isoforms (21.5, 18.5, 17.0 and 14.0 kDa) was detected in OPCs, and the expression of exon 2-containing isoforms (i.e. 17.0 and 21.5 kDa) was upregulated upon treatment with T3 . In contrast, expression of MBP was inhibited by BPA.

本文言語English
ページ(範囲)21-30
ページ数10
ジャーナルNeuroendocrinology
80
1
DOI
出版ステータスPublished - 2004 1月 1
外部発表はい

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学
  • 内分泌系および自律システム
  • 細胞および分子神経科学

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