Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men and women

Akira Fujiyoshi, Takayoshi Ohkubo, Katsuyuki Miura, Yoshitaka Murakami, Shin Ya Nagasawa, Tomonori Okamura, Hirotsugu Ueshima

研究成果: Article査読

76 被引用数 (Scopus)

抄録

Blood pressure (BP) categories defined by systolic BP (SBP) and diastolic BP (DBP) are commonly used. However, the BP category-specific risk of cardiovascular disease (CVD) has not been thoroughly investigated in different age groups. The aim of this study was to assess long-term CVD risk and its impact according to BP categories and age group. Pooling individual data from 10 cohorts, we studied 67 309 Japanese individuals (40-89 years old) who were free of CVD at baseline: we categorized them as belonging to three age groups: middle-aged (40-64 years), elderly (65-74 years) and very elderly (75-89 years). BP was classified according to the 2009 Japanese Society of Hypertension Guidelines. Cox models were used to estimate adjusted hazard ratios for CVD deaths. We observed 1944 CVD deaths over a mean follow-up of 10.2 years. In all age groups, the overall relationship between BP category and CVD risk was positive, with a greater strength observed for younger age groups. We observed a trend of increased risk from SBP/DBP130/85 mm Hg in the very elderly, and a significant increase from SBP/DBP120/80 mm Hg in the other age groups. The population attributable fractions (PAFs) of CVD death in reference to the SBP/DBP120/80 mm Hg category ranged from 23.4% in the very elderly to 60.3% in the middle-aged. We found an overall graded increase in CVD risk with higher BP category in the very elderly. The PAFs suggest that keeping BP levels low is an important strategy for primary CVD prevention, even in an elderly population.

本文言語English
ページ(範囲)947-953
ページ数7
ジャーナルHypertension Research
35
9
DOI
出版ステータスPublished - 2012 9

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学

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