Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Kenta Gonokami; Taku Obara; Mitsuru Kobayashi; Sakiko Katada; Azusa Hara; Hirohito Metoki; Kei Asayama; Masahiro Kikuya; Takayoshi Ohkubo; Yutaka Imai

doi:10.3109/10641960903443541

Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

Kenta Gonokami, Taku Obara, Mitsuru Kobayashi, Sakiko Katada, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Yutaka Imai

研究成果: Article › 査読

7 被引用数 (Scopus)

抄録

The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

本文言語	English
ページ（範囲）	311-317
ページ数	7
ジャーナル	Clinical and Experimental Hypertension
巻	32
号	5
DOI	https://doi.org/10.3109/10641960903443541
出版ステータス	Published - 2010 8月
外部発表	はい

ASJC Scopus subject areas

内科学
生理学

文献へのアクセス

10.3109/10641960903443541

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引用スタイル

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title = "Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement",

abstract = "The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.",

keywords = "Doxazosin, Home blood pressure (HBP), Morning hypertension",

author = "Kenta Gonokami and Taku Obara and Mitsuru Kobayashi and Sakiko Katada and Azusa Hara and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Yutaka Imai",

note = "Funding Information: This work was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology and grants from the National Cardiovascular Center in Japan.",

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doi = "10.3109/10641960903443541",

language = "English",

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T1 - Blood pressure-lowering effect and duration of action of bedtime administration of doxazosin determined by home blood pressure measurement

AU - Gonokami, Kenta

AU - Obara, Taku

AU - Kobayashi, Mitsuru

AU - Katada, Sakiko

AU - Hara, Azusa

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Imai, Yutaka

N1 - Funding Information: This work was supported by Grants for Scientific Research (1854042 and 207477) from the Ministry of Education, Culture, Sports, Science and Technology and grants from the National Cardiovascular Center in Japan.

PY - 2010/8

Y1 - 2010/8

N2 - The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

AB - The effects and duration of action of bedtime administration of doxazosin 2 mg for 4 weeks on uncontrolled morning home hypertension were investigated. Morning home blood pressure (HBP) was significantly lowered by bedtime administration of doxazosin. Doxazosin significantly lowered evening HBP only in the subgroup of patients with an uncontrolled evening HBP. The evening (E)morning (M) ratio was greater in patients with an uncontrolled evening HBP than in those with a controlled evening HBP. The results suggest that bedtime administration of doxazosin effectively suppresses morning HBP in uncontrolled morning hypertensives and lowers evening HBP in uncontrolled evening hypertensives.

KW - Doxazosin

KW - Home blood pressure (HBP)

KW - Morning hypertension

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