BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Jun Kohyama, Tsukasa Sanosaka, Akinori Tokunaga, Eriko Takatsuka, Keita Tsujimura, Hideyuki Okano, Kinichi Nakashima

研究成果: Article査読

59 被引用数 (Scopus)

抄録

Once they have differentiated, cells retain their individual character and repress genes that are specifically expressed in other cell lineages, but how alternative fate choice is restricted during and/or after differentiation remains unclear. In the mammalian central nervous system, neurons, astrocytes, and oligodendrocytes are generated throughout life from common tripotent neural progenitor cells (NPCs). Bone morphogenetic proteins (BMPs) are well-known astrocyte-inducing cytokines. We show here that the expression of a transcriptional repressor, REl silencer of transcription (RESTJ/neuron- restrictive silencer factor (NRSF), is up-regulated and sustained by BMP signal activation in the course of astrocytic differentiation of NPCs, and restricts neuronal differentiation. We further show that, in differentiated astrocytes, endogenous REST/ NRSF associates with various neuronal genes and that disruption of its function resulted in their derepression, thereby explaining how ectopic neuronal gene expression is prevented in cells with astrocytic traits. Collectively, our results suggest that REST/NRSF functions as a molecular regulator of the nonneuronal phenotype in astrocytes.

本文言語English
ページ(範囲)159-170
ページ数12
ジャーナルJournal of Cell Biology
189
1
DOI
出版ステータスPublished - 2010 4 5
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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