Body mass index category as a risk factor for colorectal adenomas: A systematic review and meta-analysis

Koji Okabayashi, Hutan Ashrafian, Hirotoshi Hasegawa, Jae Hoon Yoo, Vanash M. Patel, Leanne Harling, Simon P. Rowland, Mariam Ali, Yuko Kitagawa, Ara Darzi, Thanos Athanasiou

研究成果: Review article

86 引用 (Scopus)

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Objectives: The association between increasing body weight and colorectal adenoma prevalence has been suggested to follow a similar pattern to excess weight and colorectal cancer, although the magnitude of this relationship has not been validated. The objective of this study was to quantify the association and dose-response relationship between body mass index (BMI) and colorectal adenoma prevalence in clinical trials. Methods: We systematically reviewed 23 studies (168,201 participants), which compared the prevalence of colorectal adenomas according to World Health Organization BMI categories. We assessed the effects of each BMI category on colorectal adenomas where odds ratio (OR) was used as a surrogate for effect size, and applied multivariate meta-analysis as a method of sensitivity analysis to evaluate the robustness of our findings and to analyze adenoma prevalence by multiple BMI categories simultaneously to assess for a dose-response relationship. Heterogeneity and publication bias were assessed. Results: Subjects with a BMI of ≥ 25 had a significantly higher prevalence of colorectal adenomas (OR1.24 (95% confidence interval (CI): 1.16-1.33), P=0.01) when compared with those with BMI25. Multivariate meta-analysis also confirmed a positive association between higher BMI categories and the prevalence of colorectal adenoma (BMI: 25-30 vs. BMI25; OR1.21 (95% CI: 1.07-1.38), P=0.01; BMI30 vs. BMI25; OR1.32 (95% CI: 1.18-1.48), P=0.01) and revealed a dose-response relationship. Conclusions: The positive association between obesity and colorectal adenoma prevalence demonstrates an underlying dose-response relationship according to BMI. Colorectal centers may benefit from the timely screening of obese patients for colorectal adenomas in addition to clarifying the biological role of adiposity on colorectal tumor initiation and progression.

元の言語English
ページ(範囲)1175-1185
ページ数11
ジャーナルAmerican Journal of Gastroenterology
107
発行部数8
DOI
出版物ステータスPublished - 2012 8 1

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

これを引用

Okabayashi, K., Ashrafian, H., Hasegawa, H., Yoo, J. H., Patel, V. M., Harling, L., Rowland, S. P., Ali, M., Kitagawa, Y., Darzi, A., & Athanasiou, T. (2012). Body mass index category as a risk factor for colorectal adenomas: A systematic review and meta-analysis. American Journal of Gastroenterology, 107(8), 1175-1185. https://doi.org/10.1038/ajg.2012.180