Boesenberols I–K, new isopimarane diterpenes from Boesenbergia pandurata with TRAIL-resistance overcoming activity

Utpal K. Karmakar, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

研究成果: Article査読

7 被引用数 (Scopus)

抄録

TRAIL is a promising anticancer agent due to its unique ability to kill tumor cells selectively without harming non-malignant cells. However, some cancer cells are reported to be TRAIL-resistant. Searching potent TRAIL agonist to overcome resistance is an important strategy for its successful use as an anticancer agent. As a part of our continuous research on natural inhibitors, activity-guided fractionation of the MeOH extract of Boesenbergia pandurata rhizomes afforded three (1–3) new isopimarane diterpenes, boesenberols I–K, together with two (4–5) known compounds. The structures of these new compounds were elucidated using HRESIMS, IR, 1D and 2D NMR spectroscopy. All compounds showed TRAIL-resistance overcoming activity.

本文言語English
ページ(範囲)3838-3841
ページ数4
ジャーナルTetrahedron Letters
58
40
DOI
出版ステータスPublished - 2017
外部発表はい

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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