Boronic-acid-catalyzed regioselective and stereoselective glycosylations via sni-type mechanism

研究成果: Article査読


1,2-cis-Glycosides are frequently found in various biologically active natural products. However, the stereoselective synthesis of these glycosides is still difficult due to the lack of neighboring group participation. Therefore, the development of efficient synthetic methods has been required. In this context, we have reported novel regio-and 1,2-cis-α-stereoselective glycosylations using 1,2-anhydroglycosyl donors and diol acceptor-derived boronic ester catalysts without additives under mild conditions. In addition, development of 1,2-cis-stereoselective glycosylations using mono-ol acceptor-derived borinic esters and their application to the total synthesis of natural glycolipids were also reported. In this mini-review, further extended studies on boronic-acid-catalyzed regio-and stereoselective glycosylations are introduced.

ジャーナルTrends in Glycoscience and Glycotechnology
出版ステータスPublished - 2019 7 1

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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