Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues

Cavit D. Kant, Yoshinobu Akiyama, Katsunori Tanaka, Susan Shea, Yohei Yamada, Sarah E. Connolly, Jose Marino, Georges Tocco, Gilles Benichou

研究成果: Article査読

1 被引用数 (Scopus)

抄録

In this study, we showed that aly/aly mice, which are devoid of lymph nodes and Peyer's patches, acutely rejected fully allogeneic skin and heart grafts. They mounted potent inflammatory direct alloresponses but failed to develop indirect alloreactivity after transplantation. Remarkably, skin allografts also were rejected acutely by splenectomized aly/aly (aly/aly-spl-) mice devoid of all secondary lymphoid organs. In these recipients, the rejection was mediated by alloreactive CD8+ T cells presumably primed in the bone marrow. In contrast, cardiac transplants were not rejected by aly/aly-spl- mice. Actually, aly/aly-spl- mice that spontaneously accepted a heart allotransplant and displayed donor-specific tolerance also accepted skin grafts from the same, but not a third-party, donor via a mechanism involving CD4+ regulatory T cells producing IL-10 cytokine. Therefore, direct priming of alloreactive T cells, as well as rejection and regulatory tolerance of allogeneic transplants, can occur in recipient mice lacking secondary lymphoid organs.

本文言語English
ページ(範囲)1364-1371
ページ数8
ジャーナルJournal of Immunology
194
3
DOI
出版ステータスPublished - 2015 2 1
外部発表はい

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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