Brain natriuretic peptide is a novel cardiac hormone

Yoshihiko Saito, Kazuwa Nakao, Hiroshi Itoh, Takayuki Yamada, Masashi Mukoyama, Hiroshi Arai, Kiminori Hosoda, Gotaro Shirakami, Shin ichi Suga, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Hiroo Imura

研究成果: Article査読

194 被引用数 (Scopus)

抄録

Using a radioimmunoassay for brain natriuretic peptide (BNP), we have measured levels of BNP-like immunoreactivity (-LI) in extract of the porcine heart, in perfusate from the isolated porcine heart and in porcine plasma. BNP-LI was detected in the extract of the atrium, though no detectable amount of BNP-LI (more than 1 ng/g) was present in the ventricle. The BNP-LI level in the porcine atrium was 148.7 ± 23.3 ng/g. BNP-LI was also detected in the perfusate from the heart. Basal secretory rate of BNP was 3.18 ± 0.76 ng/min. Moreover, BNP-LI was detected in porcine plasma at the concentration of 4.2 ± 1.3 pg/ml. Gel filtration studies showed that BNP is present in the atrium as a large molecule and is secreted into the circulation as a small molecule. The percentage of BNP-LI to atrial natriuretic peptide (ANP)-LI was almost the same among the extract, the perfusate and the plasma (2-3 percent). These results indicate that BNP is synthesized in and is secreted into the circulation from the heart in a similar fashion as ANP.

本文言語English
ページ(範囲)360-368
ページ数9
ジャーナルBiochemical and Biophysical Research Communications
158
2
DOI
出版ステータスPublished - 1989 1 31
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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