Brewers' yeast-mediated synthesis of (1S,2S)-1-(2-thienyl)-1,2-propanediol and a study on the lipase-catalyzed regioselective introduction of acyl protective group to the diol moiety

Naoki Mochizuki; Takeshi Sugai; Hiromichi Ohta; Tsutomu Yokomatsu; Shiroshi Shibuya

Brewers' yeast-mediated synthesis of (1S,2S)-1-(2-thienyl)-1,2-propanediol and a study on the lipase-catalyzed regioselective introduction of acyl protective group to the diol moiety

Naoki Mochizuki, Takeshi Sugai, Hiromichi Ohta, Tsutomu Yokomatsu, Shiroshi Shibuya

薬科学科

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

Reductive homologation of thiophenecarboxyaldehyde mediated by brewers' yeast and subsequent recrystallization provided (1S,2S)-1-(2-thienyl)-1,2-propanediol in 29% yield. A Pseudomonas lipase-catalyzed acetylation preferentially occurred on the hydroxyl group at C-1 position of the diol.

本文言語	English
ページ（範囲）	331-338
ページ数	8
ジャーナル	Heterocycles
巻	45
号	2
出版ステータス	Published - 1997 12月 1

ASJC Scopus subject areas

分析化学
薬理学
有機化学

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「Brewers' yeast-mediated synthesis of (1S,2S)-1-(2-thienyl)-1,2-propanediol and a study on the lipase-catalyzed regioselective introduction of acyl protective group to the diol moiety」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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abstract = "Reductive homologation of thiophenecarboxyaldehyde mediated by brewers' yeast and subsequent recrystallization provided (1S,2S)-1-(2-thienyl)-1,2-propanediol in 29% yield. A Pseudomonas lipase-catalyzed acetylation preferentially occurred on the hydroxyl group at C-1 position of the diol.",

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AU - Ohta, Hiromichi

AU - Yokomatsu, Tsutomu

AU - Shibuya, Shiroshi

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AB - Reductive homologation of thiophenecarboxyaldehyde mediated by brewers' yeast and subsequent recrystallization provided (1S,2S)-1-(2-thienyl)-1,2-propanediol in 29% yield. A Pseudomonas lipase-catalyzed acetylation preferentially occurred on the hydroxyl group at C-1 position of the diol.

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