Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh, Luis Augusto Eijy Nagai, Kosuke Hashimoto, Sung Joon Park, Aoi Shibuya, Ana Maria Suzuki, Yujiro Tanaka, Kenta Nakai, Piero Carninci, Hiroyuki Sasaki, Haruhiko Siomi

研究成果: Article

3 引用 (Scopus)

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Genome-wide de novo DNA methylation occurs in mouse gonocytes, arrested male embryonic germ cells. However, how the methylome gets established in the genome of arrested cells remains unexplored. Yamanaka et al. report that multiple chromatin reprogramming pathways allow the access of methyltransferases to DNA in gonocytes.

元の言語English
ページ(範囲)21-34.e5
ジャーナルDevelopmental Cell
51
発行部数1
DOI
出版物ステータスPublished - 2019 10 7

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

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  • これを引用

    Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H., & Siomi, H. (2019). Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation. Developmental Cell, 51(1), 21-34.e5. https://doi.org/10.1016/j.devcel.2019.07.023