c-erbB-2 gene product associates with catenins in human cancer cells

Atsushi Ochiai, Shingo Akimoto, Yae Kanai, Tatsuhiro Shibata, Tsukasa Oyama, Setsuo Hirohashi

研究成果: Article査読

140 被引用数 (Scopus)

抄録

Phosphorylation of β-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proved to be mediated through β-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.

本文言語English
ページ(範囲)73-78
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
205
1
DOI
出版ステータスPublished - 1994 11 30
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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