TY - JOUR
T1 - c-erbB-2 gene product associates with catenins in human cancer cells
AU - Ochiai, Atsushi
AU - Akimoto, Shingo
AU - Kanai, Yae
AU - Shibata, Tatsuhiro
AU - Oyama, Tsukasa
AU - Hirohashi, Setsuo
PY - 1994/11/30
Y1 - 1994/11/30
N2 - Phosphorylation of β-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proved to be mediated through β-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.
AB - Phosphorylation of β-catenin, an intracytoplasmic cadherin-binding protein, causes disruption of the cadherin-mediated cell adhesion system in cancer cells. A 185-kDa phosphorylated protein, identified as the c-erbB-2 gene product, was co-immunoprecipitated with the E-cadherin-catenin complex. Association of the c-erbB-2 gene product with the cadherin-catenin complex was proved to be mediated through β-catenin and plakoglobin using an in vitro protein-protein precipitation system. These results indicate that the c-erbB-2 gene product associates with catenins and may regulate the cell adhesion and invasive growth of cancer.
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U2 - 10.1006/bbrc.1994.2631
DO - 10.1006/bbrc.1994.2631
M3 - Article
C2 - 7999105
AN - SCOPUS:0028001677
SN - 0006-291X
VL - 205
SP - 73
EP - 78
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 1
ER -
