c-erbB-2 Gene Product Directly Associates with β-Catenin and Plakoglobin

Y. Kanai, A. Ochiai, T. Shibata, T. Oyama, S. Ushijima, S. Akimoto, S. Hirohashi

研究成果: Article査読

149 被引用数 (Scopus)

抄録

Association of the c-erbB-2 oncogene product with the cadherin-catenin complex has been demonstrated in human cancer cell lines. Although β-catenin and plakoglobin have been proven to be crucial for the association, no previous study has shown whether the interactions are direct or indirect. In the present study, the c-erbB-2 gene product was shown by far-Western blotting analysis to associate directly with both β-catenin and plakoglobin through its cytoplasmic domain core region, which showed extensive homology with epidermal growth factor receptor. These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through β-catenin and plakoglobin in cancers.

本文言語English
ページ(範囲)1067-1072
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
208
3
DOI
出版ステータスPublished - 1995 3月 28
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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