C-peptide immunoreactivity index is associated with improvement of HbA1c: 2-Year follow-up of sitagliptin use in patients with type 2 diabetes

Takeshi Nishimura, Shu Meguro, Risa Sekioka, Karin Tanaka, Yoshifumi Saisho, Junichiro Irie, Masami Tanaka, Toshihide Kawai, Hiroshi Itoh

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Aims: This retrospective study aimed to determine the hypoglycaemic effect of 2 years of sitagliptin administration in terms of changes in HbA1c and C-peptide immunoreactivity (CPR) index (plasma CPR [ng/mL]/glucose [mg/dL]. ×. 100). Methods: The inclusion criteria for DPP-4 inhibitor-naive outpatients with type 2 diabetes (. n=. 285) were: continuation of sitagliptin for ≥700 days from initial administration and measurement of HbA1c, serum CPR, and plasma glucose levels at 0, 3, 6, 12, 18, and 24 months after sitagliptin initiation. Logistic regression analyses determined the factors contributing to the response to sitagliptin, based on responder (δHbA1c ≤-0.4% [≤-4. mmol/mol]) and non-responder (δHbA1c >-0.4% [>-4. mmol/mol]) groups. Results: The HbA1c level decreased and CPR index increased from baseline to 3, 6, 12, 18, and 24 months after the start of sitagliptin administration (HbA1c: 7.4. ±. 0.8% [57. ±. 9. mmol/mol], 7.3. ±. 0.9% [57. ±. 9. mmol/mol], 7.4. ±. 0.9% [58. ±. 10. mmol/mol], 7.1. ±. 0.8% [55. ±. 9. mmol/mol], and 7.3. ±. 0.9% [57. ±. 10. mmol/mol], respectively, all P<. 0.001 vs. baseline [8.0. ±. 1.0%, 64. ±. 11. mmol/mol] and CPR index: 1.69. ±. 0.96, 1.71. ±. 1.10, 1.62. ±. 0.96, 1.64. ±. 0.92, and 1.66. ±. 0.96, respectively, all P<. 0.05 vs. baseline [1.47. ±. 0.81]). Higher baseline HbA1c level, shorter diabetes duration, and greater CPR index increase after sitagliptin administration were associated with the response to sitagliptin. Conclusions: Our results suggest that sitagliptin improves glycaemic control via an improved intrinsic insulin response.

本文言語English
ページ(範囲)441-447
ページ数7
ジャーナルDiabetes Research and Clinical Practice
108
3
DOI
出版ステータスPublished - 2015 6 1

ASJC Scopus subject areas

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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