CaCO 3/Chitin hybrids: Recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids

Hiromu Kumagai, Ryou Matsunaga, Tatsuya Nishimura, Yuya Yamamoto, Satoshi Kajiyama, Yuya Oaki, Kei Akaiwa, Hirotaka Inoue, Hiromichi Nagasawa, Kohei Tsumoto, Takashi Kato

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Functional peptides play an important role in the formation of biominerals. Here we focus on peptides involved in mineralization of the exoskeleton of a crayfish. New recombinant peptides are designed and synthesized on the basis of an acidic functional peptide, CAP-1, derived from the exoskeleton of a crayfish. We have examined the effect of these peptides on the hybrid formation of calcium carbonate and organic molecules in aqueous solution. In the presence of these recombinant peptides having chitin binding moieties, platelike tripodal calcite crystals are formed on the chitin matrix with unidirectional crystallographic orientation. Two kinds of interactions, (1) interactions between an acidic part of the peptides and calcium ions and (2) specific binding interactions of the peptides to chitin, are essential for the formation of the oriented crystals and the induction of specific morphologies. Moreover, the sizes of crystallites decrease with increasing the number of acidic parts of mutational peptides. The bioinspired design of peptides that control the interface of inorganic and organic domains may pave the way for an opportunity to build new hybrid structures.

本文言語English
ページ(範囲)483-494
ページ数12
ジャーナルFaraday Discussions
159
DOI
出版ステータスPublished - 2012
外部発表はい

ASJC Scopus subject areas

  • 物理化学および理論化学

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