Cadherin-7 regulates mossy fiber connectivity in the cerebellum

Ken ichiro Kuwako, Yoshinori Nishimoto, Satoshi Kawase, Hirotaka James Okano, Hideyuki Okano

研究成果: Article査読

29 被引用数 (Scopus)

抄録

To establish highly precise patterns of neural connectivity, developing axons must stop growing at their appropriate destinations and specifically synapse with target cells. However, the molecular mechanisms governing these sequential steps remain poorly understood. Here, we demonstrate that cadherin-7 (Cdh7) plays a dual role in axonal growth termination and specific synapse formation during the development of the cerebellar mossy fiber circuit. Cdh7 is expressed in mossy fiber pontine nucleus (PN) neurons and their target cerebellar granule neurons during synaptogenesis and selectively mediates synapse formation between those neurons. Additionally, Cdh7 presented by mature granule neurons diminishes the growth potential of PN axons. Furthermore, knockdown of Cdh7 in PN neurons invivo severely impairs the connectivity of PN axons in the developing cerebellum. These findings reveal a mechanism by which a single bifunctional cell-surface receptor orchestrates precise wiring by regulating axonal growth potential and synaptic specificity.

本文言語English
ページ(範囲)311-323
ページ数13
ジャーナルCell Reports
9
1
DOI
出版ステータスPublished - 2014 10月 9

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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