Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity

Tomoyuki Sato, Midori A. Arai, Yixizhuoma, Yasumasa Hara, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.

本文言語English
ページ(範囲)476-481
ページ数6
ジャーナルJournal of Natural Medicines
74
2
DOI
出版ステータスPublished - 2020 3 1
外部発表はい

ASJC Scopus subject areas

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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