Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity

Tomoyuki Sato, Midori A. Arai, Yixizhuoma, Yasumasa Hara, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

研究成果: Article

抜粋

Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane sesquiterpenoids, including three new compounds (1–3), were isolated from wood extracts of Santalum album (Santalaceae). Structures of compounds 1–3 were elucidated by spectral data to have a cadinane skeleton with an aromatic ring. Of the eight compounds isolated, compound 4, identified as mansonone I, was found to be active against TOP, having an IC50 of 1.2 μM.

元の言語English
ページ(範囲)476-481
ページ数6
ジャーナルJournal of Natural Medicines
74
発行部数2
DOI
出版物ステータスPublished - 2020 3 1

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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