Calcium deficient hydroxyapatite for medical application prepared by hydrothermal method

Koji Ioku, Masanobu Kamitakahara, Tohru Ikeda

研究成果: Conference contribution

抄録

Hydrothermal processing plays a key role in the synthesis of biomaterials with excellent biocompatibility in the physiological environment. Especially, calcium phosphates are paid to much attention for the regenerative medicine. Two kinds of porous materials of hydroxyapatite with 70% porosity were prepared. One of them is a newly developed calcium-deficient hydroxyapatite composed of rod-shaped particles of about 20 μm in length synthesized hydrothermally (HHA) and the other one is the stoichiometric hydroxyapatite (SHA) prepared by the conventional sintering method. These materials were used for animal implantation tests to compare these biological responses. In the rabbit femur, implanted HHA was slowly resorbed and then most of the implanted HHA was resorbed after 72 weeks. The implanted SHA was unresorbed throughout the experimental period. The volume of newly formed bone and the number of osteoclasts in the implanted region were significantly larger in HHA than in SHA after 24 weeks. Results in the present research suggested that the activity of osteoclasts correlated to the bone forming activity of osteoblasts. The method to synthesize biodegradable pure calcium-deficient HA is expected to provide adequate biodegradability and bone replaceability.

本文言語English
ホスト出版物のタイトル2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy
ページ304-307
ページ数4
DOI
出版ステータスPublished - 2010 12月 1
外部発表はい
イベント2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy - Sanya, China
継続期間: 2009 12月 72009 12月 10

出版物シリーズ

名前AIP Conference Proceedings
1251
ISSN(印刷版)0094-243X
ISSN(電子版)1551-7616

Other

Other2nd International Symposium on Aqua Science, Water Resource and Low Carbon Energy
国/地域China
CitySanya
Period09/12/709/12/10

ASJC Scopus subject areas

  • 物理学および天文学(全般)

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