抄録
The infection by the malaria parasite of its mammalian host is initiated by the asexual reproduction of the parasite within the host hepatocyte. Before the reproduction, the elongated sporozoites undergo a depolarizing morphogenesis to the spherical exo-erythrocytic form (EEF). This change can be induced in vitro by shifting the environmental conditions, in the absence of host hepatocytes. Using rodent malaria parasites expressing a FRET-based calcium sensor, YC3.60, we observed that the intracellular calcium increased at the center of the bulbous structure during sporozoite transformation. Modulators of intracellular calcium signaling (A23187 and W-7) accelerated the sporozoite-rounding process. These data suggest that calcium signaling regulates the morphological development of the malaria parasite sporozoite to the EEF, and support a fundamental role for calcium as a universal transducer of external stimuli in the parasitic life cycle.
本文言語 | English |
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ページ(範囲) | 176-180 |
ページ数 | 5 |
ジャーナル | Experimental Parasitology |
巻 | 128 |
号 | 2 |
DOI | |
出版ステータス | Published - 2011 6月 |
ASJC Scopus subject areas
- 寄生虫科
- 免疫学
- 感染症