Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

Motoko Kawashima, Yoko Ozawa, Ken Shinmura, Takaaki Inaba, Shigeru Nakamura, Tetsuya Kawakita, Mitsuhiro Watanabe, Kazuo Tsubota

研究成果: Article査読

22 被引用数 (Scopus)

抄録

The morbidity of ocular diseases, including macular degeneration, diabetic retinopathy, and dry eye disease, has been gradually increasing worldwide. Because these diseases develop from age-associated ocular dysfunctions, interventions against the aging process itself may be a promising strategy for their management. Among the several approaches to interrupt aging processes, calorie restriction (CR) has been shown to recover and/or slow age-related functional declines in various organs, including the eye. Here, we review interventions against the aging process as potential therapeutic approaches to age-related ocular diseases. The effects of CR and CR mimetics in animal models of age-related eye diseases are explored. Furthermore, we discuss the possibilities of expanding this research to prospective studies to elucidate the molecular mechanisms by which CR and/or CR mimetics preserve ocular functions.

本文言語English
ページ(範囲)1096-1100
ページ数5
ジャーナルExperimental Gerontology
48
10
DOI
出版ステータスPublished - 2013 10月

ASJC Scopus subject areas

  • 生化学
  • 加齢科学
  • 分子生物学
  • 遺伝学
  • 内分泌学
  • 細胞生物学

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