Can pemphigus vulgaris be induced by nutritional factors?

Tadeusz P. Chorzelski, Takashi Hashimoto, Stefania Jablonska, Masayuki Amagai, Ken Ishii, Matgovrata Olszewska, Maria Jarzabek-Chorzelska

研究成果: Article

19 引用 (Scopus)

抄録

We present an unusual case of oral pemphigus vulgaris (PV) in a 42-year-old woman, in whom the lesions regressed spontaneously upon each of four hospitalizations and relapsed at home. The inducing factor was found to be leek, which was the main constituent of her three meals a day. The diagnosis of PV was confirmed by IIF, immunoblot of epidermal extract and baculovirus recombinant PVA protein. A leek-free diet produced regression of oral lesions and a fall in pemphigus antibody titers to almost undetectable levels, whereas the leek challenge induced relapse and an increase of antibody titers. It is to be presumed that the leek-induced pemphigus in our case is comparable to pemphigus induced by penicillamine and captopril or other thiol drugs in genetically predisposed individuals. It is possible that drug-induced pemphigus, which does not regress after withdrawal of the offending compound, might be maintained by the nutritional factors, if their concentration exceeds the individual threshold of tolerance.

元の言語English
ページ(範囲)284-286
ページ数3
ジャーナルEuropean Journal of Dermatology
6
発行部数4
出版物ステータスPublished - 1996

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Pemphigus
Onions
Penicillamine
Antibodies
Baculoviridae
Captopril
Recombinant Proteins
Sulfhydryl Compounds
Pharmaceutical Preparations
Meals
Hospitalization
Diet
Recurrence

ASJC Scopus subject areas

  • Dermatology

これを引用

Chorzelski, T. P., Hashimoto, T., Jablonska, S., Amagai, M., Ishii, K., Olszewska, M., & Jarzabek-Chorzelska, M. (1996). Can pemphigus vulgaris be induced by nutritional factors? European Journal of Dermatology, 6(4), 284-286.

Can pemphigus vulgaris be induced by nutritional factors? / Chorzelski, Tadeusz P.; Hashimoto, Takashi; Jablonska, Stefania; Amagai, Masayuki; Ishii, Ken; Olszewska, Matgovrata; Jarzabek-Chorzelska, Maria.

:: European Journal of Dermatology, 巻 6, 番号 4, 1996, p. 284-286.

研究成果: Article

Chorzelski, TP, Hashimoto, T, Jablonska, S, Amagai, M, Ishii, K, Olszewska, M & Jarzabek-Chorzelska, M 1996, 'Can pemphigus vulgaris be induced by nutritional factors?', European Journal of Dermatology, 巻. 6, 番号 4, pp. 284-286.
Chorzelski TP, Hashimoto T, Jablonska S, Amagai M, Ishii K, Olszewska M その他. Can pemphigus vulgaris be induced by nutritional factors? European Journal of Dermatology. 1996;6(4):284-286.
Chorzelski, Tadeusz P. ; Hashimoto, Takashi ; Jablonska, Stefania ; Amagai, Masayuki ; Ishii, Ken ; Olszewska, Matgovrata ; Jarzabek-Chorzelska, Maria. / Can pemphigus vulgaris be induced by nutritional factors?. :: European Journal of Dermatology. 1996 ; 巻 6, 番号 4. pp. 284-286.
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AU - Ishii, Ken

AU - Olszewska, Matgovrata

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AB - We present an unusual case of oral pemphigus vulgaris (PV) in a 42-year-old woman, in whom the lesions regressed spontaneously upon each of four hospitalizations and relapsed at home. The inducing factor was found to be leek, which was the main constituent of her three meals a day. The diagnosis of PV was confirmed by IIF, immunoblot of epidermal extract and baculovirus recombinant PVA protein. A leek-free diet produced regression of oral lesions and a fall in pemphigus antibody titers to almost undetectable levels, whereas the leek challenge induced relapse and an increase of antibody titers. It is to be presumed that the leek-induced pemphigus in our case is comparable to pemphigus induced by penicillamine and captopril or other thiol drugs in genetically predisposed individuals. It is possible that drug-induced pemphigus, which does not regress after withdrawal of the offending compound, might be maintained by the nutritional factors, if their concentration exceeds the individual threshold of tolerance.

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