Cancer epigenetics: Modifications, screening, and therapy

Einav Nili Gal-Yam, Yoshimasa Saito, Gerda Egger, Peter A. Jones

研究成果: Review article査読

210 被引用数 (Scopus)

抄録

Deregulation of gene expression is a hallmark of cancer. Although genetic lesions have been the focus of cancer research for many years, it has become increasingly recognized that aberrant epigenetic modifications also play major roles in the tumorigenic process. These modifications are imposed on chromatin, do not change the nucleotide sequence of DNA, and are manifested by specific patterns of gene expression that are heritable through many cell divisions. We review these modifications in normal and cancer cells and the evolving approaches used to study them. Additionally, we outline advances in their potential use for cancer diagnostics and targeted epigenetic therapy.

本文言語English
ページ(範囲)267-280
ページ数14
ジャーナルAnnual Review of Medicine
59
DOI
出版ステータスPublished - 2008 2月 28
外部発表はい

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

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