Cancer immunotherapy by immuno-checkpoint blockade

Yutaka Kawakami

研究成果: Article

抜粋

As cancer immunotherapies utilizing anti-tumor T-cell responses, immuno-checkpoint blockade and adoptive T-cell immunotherapy have recently achieved durable responses even in advanced cancer patients with metastases. Administration of antibodies on the T-cell surface, CTLA-4 and PD-1 (or PD-1 ligand PD-L1), resulted in tumor regression of not only melanoma and renal cell cancer which were known to be relatively sensitive to immunotherapy, but also various malignancies including lung, bladder, ovarian, gastric, and head and neck cancers, as well as hematological malignancies such as Hodgkin and B-cell malignant lymphomas. These findings have changed the status of immunotherapy in the development of cancer treatments. Currently, development of combinations employing cancer immunotherapy with immuno-checkpoint blockade, as well as personalized cancer immunotherapy based on the evaluation of pretreatment immune status, are in progress.

元の言語English
ページ(範囲)2186-2194
ページ数9
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
56
発行部数10
DOI
出版物ステータスPublished - 2015 10 1

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ASJC Scopus subject areas

  • Medicine(all)

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