Cancer pharmacogenomics: International trends

Yasuko Yamayoshi, Emiko Iida, Yusuke Tanigawara

研究成果: Review article査読

25 被引用数 (Scopus)

抄録

It is well known that inter-individual variability exists in the responses to many drugs. Many nongenetic factors, such as age, sex, diet, and organ function, are known to affect the therapeutic effects of drugs. However, recent advances in pharmacogenomics have revealed that genetic polymorphisms also significantly influence both the efficacy and the toxicity of drugs. Mutations in the genes encoding drug-metabolizing enzymes, transporters, and target molecules may alter their expression, activity, or affinity to drugs, thereby influencing the drugs' pharmacokinetics and pharmacodynamics. Numerous studies have reported on the correlations between therapeutic outcomes and polymorphisms in drug-metabolizing enzymes, transporters, target molecules, and DNA repair enzymes. These pharmacogenomic discoveries are expected to be useful for the individualization and optimization of cancer chemotherapy.

本文言語English
ページ(範囲)5-13
ページ数9
ジャーナルInternational Journal of Clinical Oncology
10
1
DOI
出版ステータスPublished - 2005 2月

ASJC Scopus subject areas

  • 外科
  • 血液学
  • 腫瘍学

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