Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma

Michiie Sakamoto, Taisuke Mori, Yohei Masugi, Kathryn Effendi, Irie Rie, Wenlin Du

研究成果: Article査読

44 被引用数 (Scopus)

抄録

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. HCC occurs mainly in chronically diseased livers, e.g. following hepatitis B and C infection. These high-risk patients are closely followed up, and increasing numbers of small equivocal lesions are detected by imaging diagnosis. They are now widely recognized as precursor or early-stage HCCs and are classified as dysplastic nodule or early HCC. These lesions lack typical imaging and histology of ordinary HCC and do not show elevated serum markers of α-fetoprotein and PIVKA-II, for example. Molecular analysis of these lesions would help to develop molecular markers for objective histological diagnosis of early HCC and possibly new serum markers for early detection of HCC. It has been reported that HSP70, CAP2, glypican 3 and glutamine synthetase could serve as molecular markers for early HCC. Further analysis is expected to evaluate their usefulness in routine pathological diagnosis including biopsy diagnosis and also as serum markers for early detection of HCC.

本文言語English
ページ(範囲)42-45
ページ数4
ジャーナルIntervirology
51
SUPPL. 1
DOI
出版ステータスPublished - 2008 6 1

ASJC Scopus subject areas

  • ウイルス学
  • 感染症

フィンガープリント

「Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル