Capillary Electromigration Techniques in Metabolomics

Akiyoshi Hirayama, Tomoyoshi Soga

研究成果: Chapter

1 被引用数 (Scopus)

抄録

This chapter provides an overview of the application of capillary electromigration techniques, particularly capillary electrophoresis-mass spectrometry (CE MS), in metabolomics. Compared with other metabolomics platforms, CE MS offers a number of advantages, including high sensitivity and ability to separate most charged metabolites. Therefore, it is well suited for the analysis of intermediate metabolites in energy metabolism, such as glycolysis, pentose phosphate pathway and tricarboxylic acid (TCA) cycle, which are mostly negatively charged. First the technical aspects of CE MS are covered, including CE separation modes, MS types, interface and microfluidics systems and data analysis strategies. Subsequently, applications of CE MS in targeted and non targeted metabolomics are described in detail.

本文言語English
ホスト出版物のタイトルChromatographic Methods in Metabolomics
編集者Tuulia Hyotylainen, Susanne Wiedmer
出版社Royal Society of Chemistry
ページ114-137
ページ数24
18
ISBN(印刷版)9781849736077
DOI
出版ステータスPublished - 2013 1 1

出版物シリーズ

名前RSC Chromatography Monographs
番号18
2013-January
ISSN(印刷版)1757-7055
ISSN(電子版)1757-7063

ASJC Scopus subject areas

  • 分析化学
  • 生化学
  • 化学工学(その他)

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