Capillary model of crystal microchannel for red blood cell deformability measurement

Kosuke Tsukada, Eiichi Sekizuka, Chikara Oshio, Takahiro Nagai, Haruyuki Minamitani

研究成果: Conference article査読

1 被引用数 (Scopus)

抄録

To measure red blood cell (RBC) deformability in vitro, we used microchannels on a crystal substrate as a capillary model. We observed axisymmetry deformed RBCs to estimate their deformability and decided deformability index directly from RBCs themselves. The flowing RBCs in 200 folds through microscopy were recorded with an image-intensified high speed video camera-system. This system allowed us to record individual RBC images clearly. We confirmed that the crystal microchannel is a valuable tool for RBC deformability measurement. Microangiopathy is a characteristic complication of diabetes mellitus. The decrease of RBC deformability is thought to cause this complication. In order to identify the deference in RBCs deformability between normal and diabetic RBCs. We could confirm that deformability of diabetic RBCs were much lower than normal ones, and this result suggests a possibility of serious damage in diabetic microcirculation.

本文言語English
ページ(範囲)2375-2376
ページ数2
ジャーナルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
6
出版ステータスPublished - 1997 12月 1
イベントProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
継続期間: 1997 10月 301997 11月 2

ASJC Scopus subject areas

  • 信号処理
  • 生体医工学
  • コンピュータ ビジョンおよびパターン認識
  • 健康情報学

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