Carbohydrate antigens and liver metastasis in colorectal cancer.

H. Hasegawa, M. Watanabe, Y. Arisawa, T. Teramoto, S. Kodaira, M. Kitajima

研究成果: Article

16 引用 (Scopus)

抄録

A comparative immunohistochemical study was performed to analyse the expression of cancer-associated carbohydrate antigens by primary and metastatic lesions of colon cancer. We used monoclonal antibodies which reacted with Lea, Lex and Tn as well as their sialylated derivatives. Twenty-one primary lesions in patients without metastasis and 26 primary and metastatic lesions in patients with liver metastasis were studied. Sialyl Lea was expressed by 57% of the primary lesions of patients without metastasis, 65% of the primary lesions of patients with metastasis and 73% of their liver metastases. Sialyl Lex was expressed by 60% of the primary lesions of patients with and without metastasis as well as by approximately 80% of the liver metastases. Sialyl Lea and sialyl Lex showed strong expressions in the liver metastases, significantly greater than in the primary lesions. The findings indicate the increased expressions of sialyl Lea and sialyl Lex to be correlated with liver metastasis of colorectal cancer.

元の言語English
ページ(範囲)336-341
ページ数6
ジャーナルJapanese Journal of Clinical Oncology
23
発行部数6
出版物ステータスPublished - 1993 12

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Colorectal Neoplasms
Carbohydrates
Neoplasm Metastasis
Antigens
Liver
Tumor-Associated Carbohydrate Antigens
Colonic Neoplasms
Monoclonal Antibodies
5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine

ASJC Scopus subject areas

  • Oncology

これを引用

Hasegawa, H., Watanabe, M., Arisawa, Y., Teramoto, T., Kodaira, S., & Kitajima, M. (1993). Carbohydrate antigens and liver metastasis in colorectal cancer. Japanese Journal of Clinical Oncology, 23(6), 336-341.

Carbohydrate antigens and liver metastasis in colorectal cancer. / Hasegawa, H.; Watanabe, M.; Arisawa, Y.; Teramoto, T.; Kodaira, S.; Kitajima, M.

:: Japanese Journal of Clinical Oncology, 巻 23, 番号 6, 12.1993, p. 336-341.

研究成果: Article

Hasegawa, H, Watanabe, M, Arisawa, Y, Teramoto, T, Kodaira, S & Kitajima, M 1993, 'Carbohydrate antigens and liver metastasis in colorectal cancer.', Japanese Journal of Clinical Oncology, 巻. 23, 番号 6, pp. 336-341.
Hasegawa H, Watanabe M, Arisawa Y, Teramoto T, Kodaira S, Kitajima M. Carbohydrate antigens and liver metastasis in colorectal cancer. Japanese Journal of Clinical Oncology. 1993 12;23(6):336-341.
Hasegawa, H. ; Watanabe, M. ; Arisawa, Y. ; Teramoto, T. ; Kodaira, S. ; Kitajima, M. / Carbohydrate antigens and liver metastasis in colorectal cancer. :: Japanese Journal of Clinical Oncology. 1993 ; 巻 23, 番号 6. pp. 336-341.
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AU - Kitajima, M.

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