Cardiac neural crest

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Cardiac neural crest (CNC) cells are pluripotent cells derived from the dorsal neural tube that migrate and contribute to the remodeling of pharyngeal arch arteries and septation of the cardiac outflow tract (OFT). Numerous molecular cascades regulate the induction, specification, delamination, and migration of the CNC. Extensive analyses of the CNC ranging from chick ablation models to molecular biology studies have explored the mechanisms of heart development and disease, particularly involving the OFT and aortic arch (AA) system. Recent studies focus more on reciprocal signaling between the CNC and cells originated from the second heart field (SHF), which are essential for the development of the OFT myocardium, providing new insights into the molecular mechanisms underlying congenital heart diseases (CHDs) and some human syndromes.

本文言語English
論文番号a036715
ページ(範囲)1-18
ページ数18
ジャーナルCold Spring Harbor Perspectives in Biology
13
1
DOI
出版ステータスPublished - 2021

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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