Cardiac sarcoma showing bone formation and neurogenic markers: Report of a case

H. Okita, T. Hirotani, H. Kodama, H. Orikasa, B. P. Eyden, K. Yamazaki

研究成果: Article査読


A 54 year-old Japanese female with cardiac insufficiency was found to have a left atrial mass and smaller masses on the mitral valve. Excisional surgery of the masses and mitral valve replacement were carried out. In spite of intensive post-operative radiation therapy, the patient died of intra-atrial recurrence and brain metastases after 8 months. Tumour cells were spindled to oval, were positive for vimentin, S100 protein and neurone specific enolase. Laminin and fibronectin were also demonstrated. Bone formation and myxoid areas were present. An ultrastructurally identifiable stromal component, possibly responsible for laminin and fibronectin staining, was also present. The merits of the two main diagnostic possibilities - a mesenchymal/fibroblastic sarcoma showing bone and aberrant S100 protein, and a malignant peripheral nerve sheath tumour with bone - were discussed. In practical terms, the tumour was given the diagnosis of unclassifiable sarcoma of the left atrium. Atrial sarcomas showing neural markers and bone formation are exceedingly rare, and this report adds a further exceptionally uncommon case to the literature.

ジャーナルJournal of submicroscopic cytology and pathology
出版ステータスPublished - 2002 1 1

ASJC Scopus subject areas

  • 病理学および法医学
  • 組織学
  • 細胞生物学


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