Cardiovascular disease modeling using patient-specific induced pluripotent stem cells

Atsushi Tanaka, Shinsuke Yuasa, Koichi Node, Keiichi Fukuda

研究成果: Review article査読

32 被引用数 (Scopus)

抄録

The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of genetically heritable heart diseases such as arrhythmias and cardiomyopathies, have been modeled on cell culture dishes using disease-specific iPSC-derived cardiomyocytes. These model systems can potentially provide new insights into disease mechanisms and drug discoveries. This review focuses on recent progress in cardiovascular disease modeling using iPSCs, and discusses problems and future perspectives concerning their use.

本文言語English
ページ(範囲)18894-18922
ページ数29
ジャーナルInternational journal of molecular sciences
16
8
DOI
出版ステータスPublished - 2015 8月 12

ASJC Scopus subject areas

  • 触媒
  • 分子生物学
  • 分光学
  • コンピュータ サイエンスの応用
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

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