Case report: Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation

S. Irie, H. Ogura, S. I. Okamoto, A. Tojo, K. Tani, K. Ikebuchi, N. Satoh, K. Ozawa, S. Asano

研究成果: Article

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Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.

元の言語English
ページ(範囲)316-318
ページ数3
ジャーナルAmerican Journal of the Medical Sciences
303
発行部数5
DOI
出版物ステータスPublished - 1992 1 1
外部発表Yes

ASJC Scopus subject areas

  • Medicine(all)

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