TY - JOUR
T1 - Case report
T2 - Alternation therapy with antileukemic agents and recombinant human granulocyte colony-stimulating factor for RAEB in transformation
AU - Irie, S.
AU - Ogura, H.
AU - Okamoto, S. I.
AU - Tojo, A.
AU - Tani, K.
AU - Ikebuchi, K.
AU - Satoh, N.
AU - Ozawa, K.
AU - Asano, S.
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.
AB - Under the assumption that in some patients with refractory anemia with excess of blasts (RAEB), the abnormal clones might be less responsive to granulocyte colony-stimulating factor than normal clones, the authors tried alternation therapy with a recombinant form of this factor (rhG-CSF) and antileukemic agents in the treatment of two patients with RAEB in transformation. After repetition of the short-cycled alternation therapy, the hematologic findings of both patients were completely normalized and have remained so without any adverse side effects under the continuation of this therapy for more than 5 months. Judging from our clinical experience, the alternation therapy may be a new efficient therapeutic strategy for RAEB and some types of slowly progressive leukemia.
KW - Alternation therapy
KW - Antileukemic agents
KW - Recombinant human granulocyte colony-stimulating factor
KW - Refractory anemia with excess of blasts in transformation
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U2 - 10.1097/00000441-199205000-00009
DO - 10.1097/00000441-199205000-00009
M3 - Article
C2 - 1374583
AN - SCOPUS:0026735803
VL - 303
SP - 316
EP - 318
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
SN - 0002-9629
IS - 5
ER -