Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination

S. Hisahara, J. Yuan, T. Momoi, H. Okano, M. Miura

研究成果: Article査読

107 被引用数 (Scopus)

抄録

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory diseases of the central nervous system (CNS) characterized by localized areas of demyelination. The mechanisms underlying oligodendrocyte (OLG) injury in MS and EAE remain unknown. Here we show that caspase-11 plays crucial roles in OLG death and pathogenesis in EAE. Caspase-11 and activated caspase-3 were both expressed in OLGs in spinal cord EAE lesions. OLGs from caspase-11-deficient mice were highly resistant to the cell death induced by cytotoxic cytokines. EAE susceptibility and cytokine concentrations in the CNS were significantly reduced in caspase-11-deficient mice. Our findings suggest that OLG death is mediated by a pathway that involves caspases-11 and -3 and leads to the demyelination observed in EAE.

本文言語English
ページ(範囲)111-122
ページ数12
ジャーナルJournal of Experimental Medicine
193
1
DOI
出版ステータスPublished - 2001 1月 1
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

フィンガープリント

「Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル