Caspase activity is required for nephrogenesis in the developing mouse metanephros

Takashi Araki, Takao Saruta, Hideyuki Okano, Masayuki Miura

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Programmed cell death is a mechanism through which organisms get rid of unwanted cells and is thought to be an important process in organogenesis. Although large-scale cell death is observed in the developing kidney, the precise roles of cell death in kidney organogenesis remain to be elucidated. To address this question, we prevented cell death in metanephric explants by applying caspase inhibitors. Administration of caspase inhibitors (Z-D- CH2DCB and Ac-DEVD-CHO) effectively prevented the cell death that is normally observed in nondifferentiating mesenchymal cells. Both ureteric bud branching and nephrogenesis were prevented by caspase inhibition. Our results suggest that caspases are crucial in kidney organogenesis and cell death in the nondifferentiating mesenchyme.

本文言語English
ページ(範囲)423-429
ページ数7
ジャーナルExperimental Cell Research
248
2
DOI
出版ステータスPublished - 1999 5 1
外部発表はい

ASJC Scopus subject areas

  • Cell Biology

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