Ca2+ release from Ca2+ stores, particularly from ryanodine-sensitive Ca2+ stores, is required for the induction of LTD in cultured cerebellar Purkinje cells

K. Kohda, T. Inoue, K. Mikoshiba

研究成果: Article

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1. Primary-cultured cerebellar Purkinje cells (PCs) from mouse embryos were whole cell voltage clamped, and L-glutamate (Glu) was applied iontophoretically to the dendrite. Long-term depression (LTD) of Glu-evoked currents was induced through the conjunction of repeated depolarizations and Glu applications. 2. Thapsigargin, a specific inhibitor of Ca2+-ATPase on the endoplasmic reticulum, and ryanodine and ruthenium red, inhibitors of the ryanodine receptor, blocked the induction of LTD. 3. Thapsigargin and ryanodine alone did not affect influx of Ca2+ through voltage-gated Ca2+ channels and inward currents evoked by Glu applications. 4. Our results suggest that Ca2+ release from internal stores, particularly from ryanodine-sensitive stores, is necessary for the induction of LTD in cultured PCs.

元の言語English
ページ(範囲)2184-2188
ページ数5
ジャーナルJournal of Neurophysiology
74
発行部数5
DOI
出版物ステータスPublished - 1995 1 1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

フィンガープリント Ca<sup>2+</sup> release from Ca<sup>2+</sup> stores, particularly from ryanodine-sensitive Ca<sup>2+</sup> stores, is required for the induction of LTD in cultured cerebellar Purkinje cells' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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