Catalytic asymmetric conjugate addition of thiols to α,β- unsaturated thioamides: Expeditious access to enantioenriched 1,5-benzothiazepines

Takanori Ogawa, Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

47 被引用数 (Scopus)

抄録

Softly does it: The title reaction proceeded under proton transfer conditions with a catalyst prepared from commercially available reagents to afford the desired product in high enantioselectivity. The reaction was compatible with a free amino group, thus allowing for expeditious access to enantiomerically enriched 1,5-benzothiazepines, which are important chemical entities in medicinal chemistry.

本文言語English
ページ(範囲)8551-8554
ページ数4
ジャーナルAngewandte Chemie - International Edition
51
34
DOI
出版ステータスPublished - 2012 8月 20
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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