TY - JOUR
T1 - Catalytic enantioselective protonation of cobalt-enolate equivalents generated by 1,4-reduction with borohydride
AU - Ohtsuka, Yuhki
AU - Ikeno, Taketo
AU - Yamada, Tohru
PY - 2003/4/18
Y1 - 2003/4/18
N2 - In the presence of a catalytic amount of the optically active β-ketoiminato cobalt(II) complex and borohydride modified with appropriate alcohols, the 1,4-reduction of α-substituted-α,β-unsaturated carboxamides followed by in situ enantioselective protonation proceeded smoothly to afford optically active α-substituted carboxamides with good enantiomeric excess.
AB - In the presence of a catalytic amount of the optically active β-ketoiminato cobalt(II) complex and borohydride modified with appropriate alcohols, the 1,4-reduction of α-substituted-α,β-unsaturated carboxamides followed by in situ enantioselective protonation proceeded smoothly to afford optically active α-substituted carboxamides with good enantiomeric excess.
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U2 - 10.1016/S0957-4166(03)00092-2
DO - 10.1016/S0957-4166(03)00092-2
M3 - Article
AN - SCOPUS:0037453381
SN - 0957-4166
VL - 14
SP - 967
EP - 970
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
IS - 8
ER -