Catalytic Formation of α-Aryl Ketones by C-H Functionalization with Cyclic Alkenyl Carbonates and One-Pot Synthesis of Isocoumarins

Yusuke Hara, Shunsuke Onodera, Takuya Kochi, Fumitoshi Kakiuchi

研究成果: Article査読

47 被引用数 (Scopus)

抄録

We report here a method for direct catalytic introduction of simple α-acylalkyl groups via rhodium-catalyzed C-H functionalization with cyclic alkenyl carbonates, synthetic equivalents to enolates bearing leaving groups. The reaction proceeded smoothly without using bases to give α-aryl ketones in high yields. Various nitrogen-containing aromatic rings and amide groups serve as directing groups. 3-Substituted isocoumarins can also be prepared by one-pot C-H functionalization/cyclization.

本文言語English
ページ(範囲)4850-4853
ページ数4
ジャーナルOrganic Letters
17
19
DOI
出版ステータスPublished - 2015 10月 2

ASJC Scopus subject areas

  • 有機化学
  • 物理化学および理論化学
  • 生化学

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