抄録
Cbln1 is a newly identified synaptic organizer belonging to the C1q family. Unlike other synaptic organizers, a deficiency in Cbln1 is sufficient to cause a severe reduction in the number of synapses between cerebellar Purkinje cells and parallel fibers (PFs). Furthermore, Cbln1 can rapidly induce synaptogenesis and is necessary for maintaining normal synapses in the mature cerebellum in vivo. Cbln1 was recently identified as the missing ligand for the orphan glutamate receptor δ2 (GluD2), which is expressed in Purkinje cells. Furthermore, Cbln1 released from PFs binds to neurexin (NRX) expressed on the presynaptic PFs and GluD2 at the postsynaptic site. The NRX/Cbln1/GluD2 tripartite complex is resistant to low extracellular Ca2+ levels and serves as a unique bidirectional synaptic organizer.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 215-220 |
| ページ数 | 6 |
| ジャーナル | Current Opinion in Neurobiology |
| 巻 | 21 |
| 発行部数 | 2 |
| DOI | |
| 出版物ステータス | Published - 2011 4 |
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ASJC Scopus subject areas
- Neuroscience(all)
これを引用
Cbln1 and its family proteins in synapse formation and maintenance. / Yuzaki, Michisuke.
：: Current Opinion in Neurobiology, 巻 21, 番号 2, 04.2011, p. 215-220.研究成果: Article
}
TY - JOUR
T1 - Cbln1 and its family proteins in synapse formation and maintenance
AU - Yuzaki, Michisuke
PY - 2011/4
Y1 - 2011/4
N2 - Cbln1 is a newly identified synaptic organizer belonging to the C1q family. Unlike other synaptic organizers, a deficiency in Cbln1 is sufficient to cause a severe reduction in the number of synapses between cerebellar Purkinje cells and parallel fibers (PFs). Furthermore, Cbln1 can rapidly induce synaptogenesis and is necessary for maintaining normal synapses in the mature cerebellum in vivo. Cbln1 was recently identified as the missing ligand for the orphan glutamate receptor δ2 (GluD2), which is expressed in Purkinje cells. Furthermore, Cbln1 released from PFs binds to neurexin (NRX) expressed on the presynaptic PFs and GluD2 at the postsynaptic site. The NRX/Cbln1/GluD2 tripartite complex is resistant to low extracellular Ca2+ levels and serves as a unique bidirectional synaptic organizer.
AB - Cbln1 is a newly identified synaptic organizer belonging to the C1q family. Unlike other synaptic organizers, a deficiency in Cbln1 is sufficient to cause a severe reduction in the number of synapses between cerebellar Purkinje cells and parallel fibers (PFs). Furthermore, Cbln1 can rapidly induce synaptogenesis and is necessary for maintaining normal synapses in the mature cerebellum in vivo. Cbln1 was recently identified as the missing ligand for the orphan glutamate receptor δ2 (GluD2), which is expressed in Purkinje cells. Furthermore, Cbln1 released from PFs binds to neurexin (NRX) expressed on the presynaptic PFs and GluD2 at the postsynaptic site. The NRX/Cbln1/GluD2 tripartite complex is resistant to low extracellular Ca2+ levels and serves as a unique bidirectional synaptic organizer.
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UR - http://www.scopus.com/inward/citedby.url?scp=79955650804&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2011.01.010
DO - 10.1016/j.conb.2011.01.010
M3 - Article
C2 - 21342763
AN - SCOPUS:79955650804
VL - 21
SP - 215
EP - 220
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 2
ER -