CCND1 Amplification Predicts Sensitivity to Chemotherapy and Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma

Ryuichiro Ishiguro, Masato Fujii, Taku Yamashita, Masatsugu Tashiro, Toshiki Tomita, Kaoru Ogawa, Kaori Kameyama

研究成果: Article

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Background: Cyclin D1 has been reported to be associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). Patients and Methods: FISH was performed on 58 patients. Thirty-two received neoadjuvant chemotherapy (NAC) as primary treatment and 21 with hypopharyngeal squamous cell carcinoma (HPC) received chemoradiotherapy. Results: CCND1 amplification was identified in 31 (53%) patients and the incidence was higher in HPC (p=0.0068). Four (31%) out of 13 patients with CCND1 amplification responded to NAC whereas the response rate in the non-amplified group was 79% (p=0.011). CCND1 amplification with a homogeneously staining region (HSR) was accompanied by cyclin D1 protein overexpression (p<0.0001). HPC showed HSR more frequently (p=0.033) and the survival rate of the subgroup with HSR was lower than that without (p<0.05). Conclusion: Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.

元の言語English
ページ(範囲)5213-5220
ページ数8
ジャーナルAnticancer research
23
発行部数6 D
出版物ステータスPublished - 2003 11 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Ishiguro, R., Fujii, M., Yamashita, T., Tashiro, M., Tomita, T., Ogawa, K., & Kameyama, K. (2003). CCND1 Amplification Predicts Sensitivity to Chemotherapy and Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma. Anticancer research, 23(6 D), 5213-5220.