CCR9+ plasmacytoid dendritic cells in the small intestine suppress development of intestinal inflammation in mice

Shinta Mizuno, Takanori Kanai, Yohei Mikami, Tomohisa Sujino, Yuichi Ono, Atsushi Hayashi, Tango Handa, Atsuhiro Matsumoto, Nobuhiro Nakamoto, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Hiromasa Takaishi, Toshifumi Hibi

研究成果: Article査読

25 被引用数 (Scopus)

抄録

Almost all mice lacking specific molecules associated with regulatory T cells or barrier function develop intestinal inflammation in the colon, but not in the small intestine (SI). Therefore, intestinal homeostasis of the SI may be tightly controlled by other mechanisms. To determine the role of CCR9+ plasmacytoid dendritic cells (pDCs) in intestinal homeostasis of the SI we transferred CD4+CD45RBhigh T cells into ccr9-/-×rag-2-/- mice. We showed that CCL25, a counterpart chemokine for CCR9, is constitutively expressed in the SI but not the colon and spleen of rag-2-/- or ccr9-/-×rag-2-/- mice before or after transfer of CD4+CD45RBhigh T cells. The ccr9-/-×rag-2-/- mice did not develop spontaneous intestinal inflammation in the SI and colon. Mice of both genotype where CD4+CD45RBhigh T cells were transferred developed colitis. However, the ccr9-/-×rag-2-/- mice also developed ileitis with marked infiltration of Th1 cells. These results suggest that CCR9+ pDCs are possibly small, regulatory, antigen-presenting cells of the intestine that suppress intestinal inflammation.

本文言語English
ページ(範囲)64-69
ページ数6
ジャーナルImmunology Letters
146
1-2
DOI
出版ステータスPublished - 2012 8 30

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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