CD10 expression in colorectal carcinoma correlates with liver metastasis

Yoshiya Fujimoto, Yukihiro Nakanishi, Shigeki Sekine, Kimio Yoshimura, Takayuki Akasu, Yoshihiro Moriya, Tadakazu Shimoda

研究成果: Article

53 被引用数 (Scopus)

抄録

PURPOSE: If it were possible to identify the features of primary colorectal carcinoma that were associated with liver metastasis, these features could be used as predictors of liver metastasis. METHODS: From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis. RESULTS: Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases. CONCLUSIONS: CD10 expression in colorectal carcinoma is a good predictor of liver metastasis.

本文言語English
ページ(範囲)1883-1889
ページ数7
ジャーナルDiseases of the colon and rectum
48
10
DOI
出版ステータスPublished - 2005 10 1
外部発表はい

ASJC Scopus subject areas

  • Gastroenterology

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