CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma

Taichi Kimura; Lei Wang; Kouichi Tabu; Hiroshi Nishihara; Yuji Mashita; Naoyuki Kikuchi; Mishie Tanino; Hiroaki Hiraga; Shinya Tanaka

doi:10.3109/07357907.2012.672607

CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma

Taichi Kimura, Lei Wang, Kouichi Tabu, Hiroshi Nishihara, Yuji Mashita, Naoyuki Kikuchi, Mishie Tanino, Hiroaki Hiraga, Shinya Tanaka

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10 of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.

本文言語	English
ページ（範囲）	390-397
ページ数	8
ジャーナル	Cancer Investigation
巻	30
号	5
DOI	https://doi.org/10.3109/07357907.2012.672607
出版ステータス	Published - 2012 6月
外部発表	はい

ASJC Scopus subject areas

腫瘍学
癌研究

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.3109/07357907.2012.672607

他のファイルとリンク

引用スタイル

@article{5dceac9374b84755a5da6b85f13d9a18,

title = "CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma",

abstract = "Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10 of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.",

keywords = "CD133, Cancer stem cell, Synovial sarcoma",

author = "Taichi Kimura and Lei Wang and Kouichi Tabu and Hiroshi Nishihara and Yuji Mashita and Naoyuki Kikuchi and Mishie Tanino and Hiroaki Hiraga and Shinya Tanaka",

note = "Funding Information: We thank Miho Nodagashira and Eiko Aoyanagi for the excellent technical assistance of immunohistochemistry. This work was supported in part by Grant-in-Aid for Scientific Research on Priority Area “Cancer”(20013001) from the Ministry of Education, Culture, Sports, Science and Technology and for Scientific Research (B) (19390386) from the Japan Society for the Promotion of Science.",

year = "2012",

month = jun,

doi = "10.3109/07357907.2012.672607",

language = "English",

volume = "30",

pages = "390--397",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

number = "5",

}

TY - JOUR

T1 - CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma

AU - Kimura, Taichi

AU - Wang, Lei

AU - Tabu, Kouichi

AU - Nishihara, Hiroshi

AU - Mashita, Yuji

AU - Kikuchi, Naoyuki

AU - Tanino, Mishie

AU - Hiraga, Hiroaki

AU - Tanaka, Shinya

N1 - Funding Information: We thank Miho Nodagashira and Eiko Aoyanagi for the excellent technical assistance of immunohistochemistry. This work was supported in part by Grant-in-Aid for Scientific Research on Priority Area “Cancer”(20013001) from the Ministry of Education, Culture, Sports, Science and Technology and for Scientific Research (B) (19390386) from the Japan Society for the Promotion of Science.

PY - 2012/6

Y1 - 2012/6

N2 - Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10 of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.

AB - Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10 of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.

KW - CD133

KW - Cancer stem cell

KW - Synovial sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84861079822&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861079822&partnerID=8YFLogxK

U2 - 10.3109/07357907.2012.672607

DO - 10.3109/07357907.2012.672607

M3 - Article

C2 - 22571340

AN - SCOPUS:84861079822

SN - 0735-7907

VL - 30

SP - 390

EP - 397

JO - Cancer Investigation

JF - Cancer Investigation

IS - 5

ER -

CD133 negatively regulates tumorigenicity via AKT pathway in synovial sarcoma

抄録

ASJC Scopus subject areas

UN SDG

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル