CD24 is expressed specifically in the nucleus pulposus of intervertebral discs

Nobuyuki Fujita, Takeshi Miyamoto, Jun Ichi Imai, Naobumi Hosogane, Toru Suzuki, Mitsuru Yagi, Kozo Morita, Ken Ninomiya, Kana Miyamoto, Hironari Takaishi, Morio Matsumoto, Hideo Morioka, Hiroo Yabe, Kazuhiro Chiba, Shinya Watanabe, Yoshiaki Toyama, Toshio Suda

研究成果: Article査読

118 被引用数 (Scopus)

抄録

Intervertebral disc (IVD) consists of a soft gelatinous material in its center, the nucleus pulposus (NP), bounded peripherally by fibrocartilage, annulus fibrosus (AF). Despite the number of patients with IVD degeneration, gene expression analysis has not been undertaken in NP and therefore little is known about the molecular markers expressed in NP. Here, we undertook a microarray screen in NP with the other nine tissues to identify the specific cell surface markers for NP. Five membrane associating molecules out of 10,490 genes were identified as highly expressing genes in NP compared with the other tissues. Among them, we identified CD24, a glycosylphosphatidylinositol (GPI) anchor protein as a cell surface marker for NP. CD24 expression was also detected in the herniated NP and chordoma, a malignant primary tumor derived from notochordal cells, while it was absent in chondrosarcoma. Therefore, CD24 is a molecular marker for NP as well as the diseases of IVD.

本文言語English
ページ(範囲)1890-1896
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
338
4
DOI
出版ステータスPublished - 2005 12月 30

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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