CD26-mediated regulation of periostin expression contributes to migration and invasion of malignant pleural mesothelioma cells

Eriko Komiya, Kei Ohnuma, Hiroto Yamazaki, Ryo Hatano, Satoshi Iwata, Toshihiro Okamoto, Nam H. Dang, Taketo Yamada, Chikao Morimoto

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Malignant pleural mesothelioma (MPM) is an aggressive malignancy arising from mesothelial lining of pleura. It is generally associated with a history of asbestos exposure and has a very poor prognosis, partly due to the lack of a precise understanding of the molecular mechanisms associated with its malignant behavior. In the present study, we expanded on our previous studies on the enhanced motility and increased CD26 expression in MPM cells, with a particular focus on integrin adhesion molecules. We found that expression of CD26 upregulates periostin secretion by MPM cells, leading to enhanced MPM cell migratory and invasive activity. Moreover, we showed that upregulation of periostin expression results from the nuclear translocation of the basic helix-loop-helix transcription factor Twist1, a process that is mediated by CD26-associated activation of Src phosphorylation. While providing new and profound insights into the molecular mechanisms involved in MPM biology, these findings may also lead to the development of novel therapeutic strategies for MPM.

本文言語English
ページ(範囲)609-615
ページ数7
ジャーナルBiochemical and Biophysical Research Communications
447
4
DOI
出版ステータスPublished - 2014 5月 16
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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