CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium

Hiroyuki Takatsu, Koji Hase, Masumi Ohmae, Sayaka Ohshima, Koji Hashimoto, Naoko Taniura, Akitsugu Yamamoto, Hiroshi Ohno

研究成果: Article査読

29 被引用数 (Scopus)

抄録

We report the characteristics of CD300LG, a member of the CD300 antigen like family. Its genomic structure is similar in both mouse and human, and at least four isoforms exist in both species. The amino acid sequence of the immunoglobulin (Ig) V like domain of CD300LG showed approximately 35% identity to those of the polymeric Ig receptor (pIgR) and Fcα/μR. Interestingly, mouse CD300LG proteins were uniquely expressed on capillary endothelium. Immunoelectron microscopy revealed that mouse CD300LG is localized on both apical and basolateral plasma membranes, as well as on intracellular vesicular structures, in the capillary endothelium. Transcytosis assays using polarized MDCK epithelial cells showed that CD300LG could be transcytosed bidirectionally. Furthermore, CD300LG exogenously expressed on HeLa cells could take up IgA2 and IgM, but not IgG. These results suggest that CD300LG might play an important role in molecular traffic across the capillary endothelium.

本文言語English
ページ(範囲)183-191
ページ数9
ジャーナルBiochemical and Biophysical Research Communications
348
1
DOI
出版ステータスPublished - 2006 9月 15
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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